- 作者：Christoffer Ros茅n ; Hans Ros茅n ; Ulf Andreasson ; Daniel Bremell ; Rosemary Bremler ; Lars Hagberg ; Lars Rosengren ; Kaj Blennow ; Henrik Zetterberg
- 关键词：Cardiac arrest ; Outcome ; Biomarkers ; Cerebrospinal fluid
- 刊名：Resuscitation
- 出版年：February, 2014
- 年：2014
- 卷：85
- 期：2
- 页码：227-232
- 全文大小：799 K
Aim
The aim of this study was to investigate the levels of various cerebrospinal fluid (CSF) biomarkers related to neuronal damage, inflammation and amyloid 尾 (A尾) metabolism in patients resuscitated after an out-of-hospital cardiac arrest (CA).Methods
CSF levels of neurofilament light protein (NFL), total tau (T-tau), hyperphosphorylated tau (P-tau), YKL-40, A尾38, A尾40, A尾42, soluble amyloid precursor protein 伪 and 尾 (sAPP伪 and sAPP尾) were measured in 21 patients approximately two weeks after CA and in 21 age-matched neurologically healthy controls. The biomarker levels were also compared between patients with good and poor long-term clinical outcome according to Glasgow Outcome Scale (GOS), activities of daily living (ADL) and mini-mental state examination (MMSE), measuring neurologic function, daily functioning and cognitive function, respectively.
Results
Patients with CA had a very marked increase in the CSF levels of NFL, T-tau and YKL-40 as compared with controls. The levels were increased at about 1200, 700 and 100%, respectively. NFL and T-tau were significantly higher in patients with poor outcome according to all three outcome measures. Patients with poor outcome according to GOS and ADL had higher levels of YKL-40. Levels of A尾38, A尾40, A尾42, sAPP伪 and sAPP尾 were lower in patients with a low MMSE score. P-tau was not significantly altered.
Conclusions
Biomarkers reflecting neuronal damage and inflammation, but not so much A尾 metabolism, were significantly altered in patients after a CA, and the changes were more pronounced in the groups with poor outcome. This calls for future larger studies to determine the prognostic potential of these biomarkers.