Cognitive decline in type 2 diabetic db/db mice may be associated with brain region-specific metabolic disorders

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• 作者：Hong Zheng^a ; Yongquan Zheng^a ; Liangcai Zhao^a ; Minjiang Chen^a ; Guanghui Bai^b ; Yongsheng Hu^a ; Wenyi Hu^a ; Zhihan Yan^b ; ^{zhihanyan@hotmail.com} ; Hongchang Gao^a ; ^{gaohc27@wmu.edu.cn}
• 关键词：ADP ; adenosine diphosphate ; Ala ; alanine ; Asp ; aspartate ; AMP ; adenosine monophosphate ; Cho ; choline ; Cre/PCre ; creatine/phosphocreatine ; FWT ; fresh weight tissue ; GABA ; γ-aminobutyric acid ; Gln ; glutamine ; Glu ; glutamate ; Gly ; glycine ; IMP ; inosine monophosphate ; Ino ; inosine ; Lac ; lactate ; Myo ; myo-inositol ; NAA ; N-acetylaspartate ; NAD  ; + ;   ; nicotinamide adenine dinucleotide ; Suc ; succinate ; T2D ; type 2 diabetes ; Tau ; taurine ; wt ; wild-type
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1863
• 期：1
• 页码：266-273
• 全文大小：1001 K
• 卷排序：1863

文摘

An increased brain anaerobic glycolysis is associated with cognitive decline in T2D. TCA and Gln-Glu/GABA cycles are inhibited in T2D mice with cognitive decline. A disturbance in lactate-alanine shuttle is responsible for cognitive decline in T2D. Brain region-specific metabolic disorders exist in T2D mice with cognitive decline.