ERCC2/XPD Lys751Gln alter DNA repair efficiency of platinum-induced DNA damage through P53 pathway

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• 作者：Guopei Zhang^a ; ¹ ; Yangyang Guan^a ; ¹ ; Yuejiao Zhao^b ; ¹ ; Tahar van der Straaten^c ; Sha Xiao^a ; Ping Xue^a ; Guolian Zhu^a ; Qiufang Liu^a ; Yuan Cai^a ; Cuihong Jin^a ; Jinghua Yang^a ; Shengwen Wu^a ; Xiaobo Lu^a ; ^{xblu@cmu.edu.cn}
• 关键词：ERCC2/XPDLys751Glnrs13181 ; Nucleotide excision repair (NER) ; DNA repair capacity (DRC) ; Cisplatin resistance ; Transfected cell model
• 刊名：Chemico-Biological Interactions
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：263
• 期：Complete
• 页码：55-65
• 全文大小：2289 K
• 卷排序：263

文摘

ERCC2 rs13181 C allele is linked with a retarded process of DNA repair. ERCC2 rs13181 C allele is related to a prolonged S phase and an increased apoptosis. ERCC2 rs13181 C allele is associated with a more serious DNA damage induced by Cisplatin.