Cognitive and emotional profiles of aged Alzheimer's disease (3 脳 TgAD) mice: Effects of environmental enrichment and sexual dimorphism
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- 作者：Gloria Blá ; zquez ; gloria.blazquez@uab.cat" class="auth_mail ; Toni Cañ ; ete antoni.canete@uab.cat" class="auth_mail ; Adolf Tobeñ ; a adolf.tobena@uab.cat" class="auth_mail ; Lydia Gimé ; nez-Llort lidia.gimenez@uab.cat" class="auth_mail ; Alberto Ferná ; ndez-Teruel albert.fernandez.teruel@uba.cat" class="auth_mail
- 关键词：Alzheimer's disease model ; Aged 3 ; × ; ; TgAD mice ; Environmental enrichment ; Learning and memory ; Anxiety ; Sexual dimorphism
- 刊名：Behavioural Brain Research
- 出版年：15 July 2014
- 年：2014
- 卷：268
- 期：Complete
- 页码：185-201
- 全文大小：1684 K
文摘
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Aged 3 × TgAD mice show deficits in spatial learning, short-term and working memory.
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3 × TgAD mice show signs of increased anxiety and normal sensorimotor functions.
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Sexual dimorphism is reflected by increased behavioral inhibition in males.
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Sexual dimorphism is reflected by increased cognitive deficits in females.
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Environmental enrichment in adulthood induces beneficial effects on working memory.