Antihypertensive and neuroprotective effects of catestatin in spontaneously hypertensive rats: Interaction with GABAergic transmission in amygdala and brainstem
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- 作者：E. Avolioa ; b ; c ; eavolio@ucsd.edu" class="auth_mail ; S.K. Mahatab ; smahata@ucsd.edu" class="auth_mail ; E. Mantuanoc ; M. Melea ; R. Alò ; a ; R.M. Faccioloa ; G. Talanid ; M. Canonacoa
- 关键词：ACS ; amino cupric silver stain ; AMY ; amygdala ; BP ; blood pressure ; CeA ; central amygdalar nucleus ; CST ; catestatin ; CTRL ; control ; HR ; heart rate ; HTN ; hypertension ; IML ; intermediolateral cell coumn ; ix ; glossopharyngeal nerve ; mACSF ; modified artificial cerebrospinal fluid ; MUS ; muscimol ; NTS ; nucleus tractus solitarius ; PVN ; paraventricular nucleus ; RVLM ; rostral ventrolateral medulla ; SHR ; spontaneously hypertensive rat ; sIPSC ; spontaneous inhibitory postsynaptic current ; x ; vagus nerve
- 刊名：Neuroscience
- 出版年：13 June 2014
- 年：2014
- 卷：270
- 期：Complete
- 页码：48-57
- 全文大小：1953 K
文摘
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CST exerted antihypertensive and neuroprotective effects.
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CST interacted with GABAergic systems and increased activities.
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Akt and ERK signaling were involved in neuroprotective mechanisms.
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CST + MUS may constitute new therapeutic agents for neurovascular disorders.