Generational change in fasting glucose and insulin among children at ages 5-16y: Modelled on the EarlyBird study (2015) and UK growth standards (1990) (EarlyBird 69)

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• 作者：Mohammod Mostazir^a ; ^b ; ^{m.mostazir@exeter.ac.uk} ; Alison Jeffery^c ; Linda Voss^a ; Terence Wilkin^a
• 关键词：Fasting glucose ; Insulin ; Generational change
• 刊名：Diabetes Research and Clinical Practice
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：123
• 期：Complete
• 页码：18-23
• 全文大小：705 K
• 卷排序：123

文摘

We modelled the change in beta cell demand from the UK BMI standards of 1990 and the EarlyBird data set of 2015. HbA1C and fasting glucose showed no change, whereas fasting insulin and HOMA2-IR suggested a substantial rise in beta cell demand, particularly in girls. Beta cell demand is an important cause of beta cell loss, and the observations provide a possible basis for the rise in dysglycaemia and type 2 diabetes among contemporary children.