Insulin kinetics and the Neonatal Intensive Care Insulin-Nutrition-Glucose (NICING) model

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• 作者：J.L. Dickson^a ; ^{jennifer.dickson@canterbury.ac.nz} ; C.G. Pretty^a ; ^{chris.pretty@canterbury.ac.nz} ; J. Alsweiler^b ; ^c ; ^{j.alsweiler@auckland.ac.nz} ; A. Lynn^d ; ^{Adrienne.Lynn@cdhb.health.nz} ; J.G. Chase^a ; ^{geoff.chase@canterbury.ac.nz}
• 关键词：Physiological modelling ; Glucose ; Insulin ; Premature infant ; Glycaemic control
• 刊名：Mathematical Biosciences
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：284
• 期：Complete
• 页码：61-70
• 全文大小：807 K
• 卷排序：284

文摘

A three compartment model of glucose–insulin kinetics in the very premature infant is presented. Insulin kinetic parameters are identified using a novel clinical data set, alongside literature data. Kidney function and extracellular fluid volumes are tailored by infant age and weight. The final model shows similar or improved ability to capture clinical data over previous model iterations, and improved glycaemic control performance in use. The final model is more physiologically comprehensive, but is still identifiable for bedside use in glycaemic control.