Beneficial metabolic actions of a stable GIP agonist following pre-treatment with a SGLT2 inhibitor in high fat fed diabetic mice

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• 作者：P.J.B. Millar^a ; V. Pathak^a ; R.C. Moffett^a ; N.M. Pathak^a ; A.J. Bjourson^b ; M.J. O'Kane^b ; ^c ; P.R. Flatt^a ; V.A. Gault^a ; ^{va.gault@ulster.ac.uk" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Dapagliflozin ; Diabetes ; Glucose-dependent insulinotropic polypeptide (GIP) ; Insulin secretion ; SGLT2 inhibitor
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2016
• 出版时间：15 January 2016
• 年：2016
• 卷：420
• 期：Complete
• 页码：37-45
• 全文大小：1417 K

文摘

<dl class="listitem" id="list_ulist0010"><dt class="label">•dt><dd>

d="p0010">(smallcaps">dAla²)GIP improved glucose tolerance, insulin secretion/sensitivity following DAPA pre-treatment.

dd><dt class="label">•dt><dd>

d="p0015">(smallcaps">dAla²)GIP reversed DAPA-induced increase in alpha cell area.

dd><dt class="label">•dt><dd>

d="p0020">DAPA treatment reversed impaired action of (smallcaps">dAla²)GIP under hyperglycaemic conditions.

dd><dt class="label">•dt><dd>

d="p0025">Possibility of therapy using a GIP agonist and SGLT2 inhibitor.

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