Fabrication and in vitro characterization of electrospun poly (γ-glutamic acid)-silica hybrid scaffolds for bone regeneration
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- 作者：Chunxia Gaoa ; b ; Shingo Itob ; Akiko Obatab ; obata.akiko@nitech.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Toshihisa Mizunob ; Julian R. Jonesc ; Toshihiro Kasugab
- 关键词：Bone regeneration ; Hybrid scaffold ; Poly (γ-glutamic acid) ; Electrospinning
- 刊名：Polymer
- 出版年：2016
- 出版时间：17 May 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：106-117
- 全文大小：4631 K
文摘
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Nanofibrous γ-NaPGA-silica hybrid scaffolds with controllable silica contents were fabricated by electrospinning.
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The introduction of NaHCO3 caused the formation of the sodium salt form of γ-PGA with solubility in aqueous-based solution.
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The results of FTIR and 29Si MAS-NMR indicated that γ-PGA and silica networks were covalent-linked with GPTMS.
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The γ-PGA-silica hybrid scaffolds can provide an excellent ECM for bone tissue regeneration.