Metabolome analysis reveals the effect of carbon catabolite control on the poly(γ-glutamic acid) biosynthesis of Bacillus licheniformis ATCC 9945
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- 作者：Hitoshi Mitsunaga1 ; hitoshi_mitsunaga@bio.eng.osaka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Lena Meissner2 ; Lena.Meissner@avt.rwth-aachen.de" class="auth_mail" title="E-mail the corresponding author ; Thomas Palmen2 ; Thomas.Palmen@avt.rwth-aachen.de" class="auth_mail" title="E-mail the corresponding author ; Takeshi Bamba1 ; 3 ; bamba@bio.eng.osaka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Jochen Bü ; chs2 ; Jochen.Buechs@avt.rwth-aachen.de" class="auth_mail" title="E-mail the corresponding author ; Eiichiro Fukusaki1 ; fukusaki@bio.eng.osaka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bacillus licheniformis ATCC 9945 ; Poly(γ-glutamic acid) ; Carbon catabolite control ; Metabolomics ; Ion-pair-liquid chromatography coupled with tandem mass spectrometry
- 刊名：Journal of Bioscience and Bioengineering
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：121
- 期：4
- 页码：413-419
- 全文大小：541 K
文摘
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This is the first report of metabolome analysis on PGA producing Bacillus licheniformis.
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This study revealed the carbon catabolite repression mechanism in PGA production.
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Pulsed addition of citrate and ammonium achieved the highest PGA production.