A superparamagnetic polymersome with extremely high T₂ relaxivity for MRI and cancer-targeted drug delivery

详细信息    查看全文

• 作者：Qiuming Liu^a ; ^b ; ¹ ; Liwen Song^a ; ¹ ; Shuai Chen^b ; Jingyi Gao^b ; Peiyu Zhao^a ; Jianzhong Du^a ; ^b ; ^{jzdu@tongji.edu.cn}
• 关键词：MRI ; Superparamagnetic iron oxide nanoparticles ; Polymersome ; Polymer vesicle ; Antitumor drug delivery ; Self-assembly
• 刊名：Biomaterials
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：114
• 期：Complete
• 页码：23-33
• 全文大小：3329 K
• 卷排序：114

文摘

Improving the relaxivity of magnetic resonance imaging (MRI) contrast agents is an important challenge for cancer theranostics. Herein we report the design, synthesis, characterization, theoretical analysis and in vivo tests of a superparamagnetic polymersome as a new MRI contrast agent with extremely high T2 relaxivity (611.6 mM−1s−1). First, a noncytotoxic cancer-targeting polymersome is synthesized based on a biodegradable diblock copolymer, folic acid-poly(l-glutamic acid)-block-poly(ε-caprolactone) [FA-PGA-b-PCL]. Then, ultra-small superparamagnetic iron oxide nanoparticles (SPIONs) are in situ generated in the hydrophilic PGA coronas of polymersomes to afford magnetic polymersomes. The in vivo MRI assay revealed prominent negative contrast enhancement of magnetic polymersomes at a very low Fe dose of 0.011 mmol/kg. Moreover, this cancer-targeting magnetic polymersome can effectively encapsulate and deliver anticancer drug to inhibit the tumor growth, demonstrating promising theranostic applications in biomedicine.