Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size: Biomarker assessment in the Hokkaido Study
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- 作者：Sumitaka Kobayashia ; b ; Fumihiro Sataa ; c ; Seiko Sasakib ; Titilola Serifat Braimoha ; b ; Atsuko Arakia ; Chihiro Miyashitaa ; Houman Goudarzia ; Sachiko Kobayashia ; Reiko Kishia ; rkishi@med.hokudai.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：AHR ; aromatic hydrocarbon receptor ; BP ; benzo[a]pyrene ; BPDE ; benzo[a]pyrene 7 ; 8-diol oxide ; CI ; confidence interval ; CYP ; cytochrome P450 ; dbSNP ; database single nucleotide polymorphism ; GST ; glutathione S-transferase ; PAH ; polycyclic aromatic hydrocarbon ; XRCC1 ; X-ray complementing repair gene 1
- 刊名：Reproductive Toxicology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：295-306
- 全文大小：2860 K
文摘
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We examined the association of prenatal smoking and polymorphism with birth size.
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Eight genotypes encoding PAH-metabolizing and DNA-repair genes were investigated.
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Polymorphisms were analyzed in 3263 healthy pregnant Japanese women.
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We observed adverse birth effects with the combination of AHR, CYP1A1 and XRCC1.
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Prenatal smoking and AHR/CYP1A1/XRCC1 SNPs are associated with reduced birth size.