The influence of changes in expression of redox-sensitive genes on the development of retinopathy in rats
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- 作者：M.L. Perepechaevaa ; perepech@niimbb.ru" class="auth_mail" title="E-mail the corresponding author ; N.G. Kolosovaa ; b ; c ; kolosova@bionet.nsc.ru" class="auth_mail" title="E-mail the corresponding author ; N.A. Stefanovab ; stefanovan@bionet.nsc.ru" class="auth_mail" title="E-mail the corresponding author ; A.Zh. Fursovab ; anzhellafursova@yandex.ru" class="auth_mail" title="E-mail the corresponding author ; A.Y. Grishanovaa ; agrish@niimbb.ru" class="auth_mail" title="E-mail the corresponding author
- 关键词：AHR ; aryl hydrocarbon receptor ; Aldh3a1 ; aldehyde dehydrogenase 3A1 ; AMD ; age-related macular degeneration ; BHQ ; black-hole quencher ; CYP1A1 ; cytochrome P450 1A1 ; CYP1A2 ; cytochrome P450 1A2 ; CYP1B1 ; cytochrome P450 1B1 ; FAM ; 6-carboxyfluorescein ; Gsr ; glutathione-S-reductase ; Gsta1 ; glutathione S-transferase A1 ; Hmox1 ; heme oxygenase 1 ; Nqo1 ; NADPH-quinone oxidoreductase ; Nrf2 ; nuclear factor erythroid derived 2 ; RPE ; retinal pigment epithelium ; Txnrd1 ; thioredoxin reductase 1 ; UDP ; uridine dip
- 刊名：Experimental and Molecular Pathology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：101
- 期：1
- 页码：124-132
- 全文大小：867 K
文摘
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OXYSb substrain differs from OXYS by normal blood pressure and milder retinopathy.
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We found interstrain differences in the expression of Nrf2- and AhR-dependent genes.
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The level of AhR autoupregulation is higher in 1-mo-old OXYSb rats than in OXYS rats.
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An imbalance between pro- and antioxidant systems may play a role in AMD development.