Glycogen storage disease type Ib neutrophils exhibit impaired cell adhesion and migration

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• 作者：Goo-Young Kim^a ; Young Mok Lee^a ; Joon Hyun Kwon^a ; Hyun Sik Jun^b ; ^{toddjun@korea.ac.kr} ; Janice Chou^a ; ^{chouja@mail.nih.gov}
• 关键词：Glucose-6-phosphate transporter ; CD11a ; CD11b ; Neutrophil adhesion ; Migration
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：569-574
• 全文大小：1485 K
• 卷排序：482

文摘

GSD-Ib deficient in G6PT is characterized by neutropenia in both blood and bone marrow. Neutrophil recruitment into peritoneal cavity is impaired in G6pt−/− and G-CSF-treated G6pt−/− mice. Neutrophils from G6pt−/− mice exhibit impaired cell migration and adhesion. The aberrant expression of β2 integrins, CD11b and CD11a may lead to impaired cell adhesion in G6pt −/− neutrophils.