Peripheral membrane proteins: Tying the knot between experiment and computation
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- 作者：Viviana Monje-Galvana ; Jeffery B. Klaudaa ; b ; jbklauda@umd.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABPP ; activity-based protein profiling ; ALPS ; amphipathic lipid packing sensor ; CERT ; ceramide transport protein ; CG ; coarse-grained ; DESRES ; D.E. Shaw research ; DMS ; DESRES molecular structure ; EM ; electron microscopy ; EPR ; electron paramagnetic resonance ; ER ; endoplasmic reticulum ; ER&ndash ; GC ; endoplasmic reticulum&ndash ; Golgi complex ; ERG ; ergosterol ; ERMES ; endoplasmic reticulum&ndash ; mitochondria encounter structure ; ESR ; electron spin resonance ; F-BAR ; F-Bin&ndash ; Amphiphysin&ndash ; Rvs ; F
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：1858
- 期：7
- 页码：1584-1593
- 全文大小：1073 K
文摘
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Peripheral membrane proteins (PMPs) participate in various cell functions from lipid transport to membrane signaling.
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To fully understand the function of PMPs, combined approaches using experiments and computation are needed.
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This review provides examples of the use of experiments and computation in understanding PMPs function.
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A simulation case study of a lipid transporter (Osh4) is presented to show how it binds to yeast organelle model membranes.