Investigation of different cross-linking approaches on 3D gelatin scaffolds for tissue engineering application: A comparative analysis

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• 作者：K. Gopal Shankar<sup>asup><sup> ; sup><sup>1sup><sup> ; sup><sup>gopal.krishnakumar2@unibo.itsup> ; Natalia Gostynska<sup>asup><sup> ; sup><sup>1sup><sup> ; sup><sup>nataliaewa.gostynska@ior.itsup> ; Monica Montesi<sup>bsup> ; Silvia Panseri<sup>bsup> ; Simone Sprio<sup>bsup> ; Elizaveta Kon<sup>asup> ; Maurilio Marcacci<sup>asup> ; Anna Tampieri<sup>bsup> ; Monica Sandri<sup>bsup>
• 关键词：Gelatin ; Dehydrothermal ; BDDGE ; Genipin ; Tissue engineering ; Cartilage
• 刊名：International Journal of Biological Macromolecules
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：95
• 期：Complete
• 页码：1199-1209
• 全文大小：2997 K
• 卷排序：95

文摘

Investigating the suitable cross-linker for gelatin for tissue engineering application. Comparative analysis on different cross-linking mechanisms (physical, chemical and natural cross-linkers). Evaluating the favourable cross-linker in terms of physical, mechanical and biological behaviour. Dehydrothermal cross-linking treatment is economical and beneficial in obtaining promising scaffolds for tissue engineering. This study would serve as a source of information about different cross-linking strategies and their future prospective use.