Krüppel-like factor 4 is a novel prognostic predictor for urothelial carcinoma of bladder and it regulates TWIST1-mediated epithelial-mesenchymal transition
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- 作者：Wei-Cheng Tsenga ; f ; Cheng-Wei Chuangb ; Muh-Hwa Yangc ; f ; h ; Chin-Chen Pand ; f ; Der-Cherng Tarngb ; e ; f ; g ; h ; dctarng@vghtpe.gov.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Epithelial-mesenchymal transition ; Krü ; ppel-like factor 4 ; TWIST1 ; Urothelial carcinoma of bladder
- 刊名：Urologic Oncology: Seminars and Original Investigations
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：34
- 期：11
- 页码：485.e15-485.e24
- 全文大小：3076 K
文摘
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KLF4/TWIST1 expression predicts metastasis and overall survival in bladder cancer.
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KLF4 promotes TWIST1-mediated EMT and tumor migration and invasion.
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KLF4/TWIST1 pathway is a potential therapeutic target for bladder cancer.