The protective efficacy aganist Schistosoma japonicum infection by immunization with DNA vaccine and levamisole as adjuvant in mice
详细信息 查看全文
- 作者：Xiao Wang ; Huali Jin ; Xiaogang Du ; Chun Cai ; Yang Yu ; Gan Zhao ; Baowei Su ; Shan Huang ; Yanxin Hu ; Dongmei Luo ; Ruiping She ; Xinsong Luo ; Xianfang Zeng ; Xinyuan Yi ; Bin Wang
- 关键词：Immune response ; Schistosoma japonicum ; DNA vaccine ; Levamisole ; Gramulomas formation
- 刊名：Vaccine
- 出版年：2008
- 出版时间：28 March 2008
- 年：2008
- 卷：26
- 期：15
- 页码：1832-1845
- 全文大小：2536 K
文摘
Levamisole (LMS) as an adjuvant enhances cell-mediated immunity in DNA vaccination; we investigated the efficacy and liver immunopathology alleviation of a DNA vaccine, VR1012-SjGST-32, in a LMS formulation in the murine challenge model. Compared to controls, the VR1012-SjGST-32 plus LMS can reduce worm and egg burdens, as well as, immunopathological complications associated chronic inflammation significantly in liver, which were apparently associated with Th1-type response. Together, these results suggest that the LMS as a potential Schistosome DNA vaccine adjuvant can enhance both worm killing and disease prevention, which is possibly mediated through the induction of a strong Th1-dominant environment in immunized mice.