Modulation on brain gray matter activity and white matter integrity by APOE ε4 risk gene in cognitively intact elderly: A multimodal neuroimaging study

详细信息    查看全文

• 作者：Suping Cai^a ; ¹ ; Yuanyuan Jiang^b ; ¹ ; Yubo Wang^a ; Xiaoming Wu^c ; Junchan Ren^a ; Min Seob Lee^d ; Sunghoon Lee^e ; Liyu Huang^a ; ^{huangly@mail.xidian.edu.cn}
• 关键词：Gray matter activity ; White matter integrity ; APOE ε4 ; Cognitively intact elderly ; fMRI ; MRI ; DTI ; Alzheimer&rsquo ; s disease
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：30 March 2017
• 年：2017
• 卷：322
• 期：part_PA
• 页码：100-109
• 全文大小：1776 K
• 卷排序：322

文摘

APOE ε4 carriers showed an increased gray matter activity in ACC and mPFC. APOE ε4 carriers showed an decreased gray matter activity in Precuneus. APOE ε4 carriers showed lower AD values in fiber of genu of corpus callosum. APOE ε4 carriers showed lower MD in fibers of corona radiata and corpus callosum.