Infection Programs Sustained Lymphoid Stromal Cell Responses and Shapes Lymph Node Remodeling upon Secondary Challenge

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• 作者：Julia L. Gregory¹ ; Anne Walter¹ ; Yannick O. Alexandre¹ ; Jyh Liang Hor¹ ; ² ; Ruijie Liu³ ; Joel Z. Ma¹ ; Sapna Devi¹ ; ² ; Nobuko Tokuda⁴ ; Yuji Owada⁵ ; Laura K. Mackay¹ ; Gordon K. Smyth³ ; ⁶ ; William R. Heath¹ ; ² ; Scott N. Mueller¹ ; ² ; ⁷ ; ^{smue@unimelb.edu.au}
• 关键词：lymphoid stromal cells ; fibroblastic reticular cells ; endothelial cells ; lymph nodes ; immune response ; virus infection ; lymphocytes
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：18
• 期：2
• 页码：406-418
• 全文大小：4567 K
• 卷排序：18

文摘

Infection induces a robust transcriptional program in lymphoid stromal cells (LSCs) The LSC transcriptional program is not sustained after resolution of infection Prolonged LSC expansion occurs after infection that is sustained by B cells Experienced LSC networks support subsequent immune responses via reduced expansion