Hospitalizations and outpatient visits for rhinovirus-associated acute respiratory illness in adults

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• 作者：E. Kathryn Miller ; MD ; MPH^a ; ^{eva.k.miller@Vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author} ; Jodell Linder ; PhD^a ; David Kraft ; MD^a ; Monika Johnson ; MS^a ; Pengcheng Lu ; MS^b ; Benjamin R. Saville ; PhD^b ; John V. Williams ; MD^c ; Marie R. Griffin ; MD ; MPH^d ; ^e ; ^f ; H. Keipp Talbot ; MD ; MPH^d
• 关键词：Rhinovirus ; acute respiratory illness ; adults ; hospitalized ; emergency department ; smoking
• 刊名：Journal of Allergy and Clinical Immunology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：137
• 期：3
• 页码：734-743.e1
• 全文大小：1227 K

文摘

Rhinovirus is linked to asthma exacerbations and chronic obstructive pulmonary disease exacerbations in adults. The severity and rates of rhinovirus acute respiratory illnesses (ARIs) in adults are uncertain.

c_2">Objectives

para0015">We sought to determine rhinovirus-associated ARI rates in adults presenting for care in multiple settings and identify factors associated with rhinovirus detection.

c_3">Methods

para0020">This prospective, population-based cohort enrolled Tennessee residents 18 years or older in the emergency department (ED), outpatient clinics, or hospitalized for ARI from December 2008 to May 2010. Nasal/throat swabs were collected and tested for rhinovirus and other viruses by using RT-PCR. Rates of ED visits and hospitalizations were calculated and rhinovirus-positive and rhinovirus-negative patients were compared.

c_4">Results

para0025">Among 2351 enrollees, rhinovirus was detected in 247 (11%). There were 7 rhinovirus-associated ED visits and 3 hospitalizations per 1000 adults annually. Patients with rhinovirus, compared with virus-negative ARI, were more likely to present with wheezing (odds ratio [OR], 1.7; 95% CI, 1.23-2.35; P < .001), to be a current smoker (OR, 2.31; 95% CI, 1.68-3.19) or live with a smoker (OR, 1.72; 95% CI, 1.10-2.67), have a history of chronic respiratory disease (OR, 1.61; 95% CI, 1.17-2.22), and were less likely to be hospitalized versus seen in the outpatient setting (OR, 0.58; 95% CI, 0.41-0.83).

c_5">Conclusions

para0030">Rhinovirus is associated with a substantial number of ED visits and hospitalizations for ARIs in adults. There may be modifiable factors that can reduce the likelihood of presenting with rhinovirus-associated ARIs.