Designed biodegradable hydrogel structures prepared by stereolithography using poly(ethylene glycol)/poly(d,l-lactide)-based resins

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• 作者：Tetsu M. Seck ; Ferry P.W. Melchels ; Jan Feijen ; Dirk W. Grijpma
• 关键词：Biodegradable hydrogels ; Designed porous structures ; Stereolithography ; Macromer photo-polymerisation ; Tissue engineering
• 刊名：Journal of Controlled Release
• 出版年：2010
• 出版时间：20 November 2010
• 年：2010
• 卷：148
• 期：1
• 页码：34-41
• 全文大小：579 K

文摘

Designed three-dimensional biodegradable poly(ethylene glycol)/poly(d,l-lactide) hydrogel structures were prepared for the first time by stereolithography at high resolutions. A photo-polymerisable aqueous resin comprising PDLLA-PEG-PDLLA-based macromer, visible light photo-initiator, dye and inhibitor in DMSO/water was used to build the structures. Porous and non-porous hydrogels with well-defined architectures and good mechanical properties were prepared. Porous hydrogel structures with a gyroid pore network architecture showed narrow pore size distributions, excellent pore interconnectivity and good mechanical properties. The structures showed good cell seeding characteristics, and human mesenchymal stem cells adhered and proliferated well on these materials.