Ag-NPs lead to inflammatory response in the intestine.
Ag-NPs reduced Caco-2 cell viability, increased ROS/RNS and lipid peroxidation.
Ag-NPs decreased secretion of the IL-8 protein and its gene expression.
Silver ions had only partial contribution in the Ag-NP-induced toxicity.
Quercetin protected the intestinal cells from the harmful effect of Ag-NPs.