Tuning the inflammatory response to silver nanoparticles via quercetin in Caco-2 (co-)cultures as model of the human intestinal mucosa
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- 作者：Alina Martirosyana ; b ; 1 ; Konstantinos Grintzalisa ; c ; 1 ; Madeleine Poleta ; Laurie Lalouxa ; Yves-Jacques Schneidera ; yjs@uclouvain.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACP ; acid phosphatase ; Ag-NPs ; silver nanoparticles ; ALP ; alkaline phosphatase ; AP ; apical ; BL ; basolateral ; CAT ; catalase ; DLS ; dynamic light scattering ; DMSO ; dimethylsulfoxide ; GIT ; gastrointestinal tract ; GR ; glutathione reductase ; GST ; glutathione-S-transferase ; HBSS ; Hank&rsquo ; s Balanced Salt Solution ; HCS ; high content screening ; IL-6 ; 8 ; interleukin 6 ; 8 ; iNOS ; inducible-NOS ; MTT ; 3-(4 ; 5 dimethylthiazol-2-yl)-2 ; 5-diphenyl tetrazolium bromide ; NBT ; nitroblue tetrazolium ; NO ; nitric oxide
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：24 June 2016
- 年：2016
- 卷：253
- 期：Complete
- 页码：36-45
- 全文大小：1546 K
文摘
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Ag-NPs lead to inflammatory response in the intestine.
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Ag-NPs reduced Caco-2 cell viability, increased ROS/RNS and lipid peroxidation.
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Ag-NPs decreased secretion of the IL-8 protein and its gene expression.
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Silver ions had only partial contribution in the Ag-NP-induced toxicity.
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Quercetin protected the intestinal cells from the harmful effect of Ag-NPs.