Pectin/carboxymethyl cellulose/microfibrillated cellulose composite scaffolds for tissue engineering

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• 作者：Neethu Ninan ; Muthunarayanan Muthiah ; In-Kyu Park ; Anne Elain ; Sabu Thomas ; Yves Grohens
• 关键词：Pectin ; Carboxymethyl cellulose ; Microfibrillated cellulose ; Lyophilisation ; Scaffold ; Porosity
• 刊名：Carbohydrate Polymers
• 出版年：2013
• 出版时间：15 October, 2013
• 年：2013
• 卷：98
• 期：1
• 页码：877-885
• 全文大小：3066 K

文摘

Highly porous three-dimensional scaffolds made of biopolymers are of great interest in tissue engineering applications. A novel scaffold composed of pectin, carboxymethyl cellulose (CMC) and microfibrillated cellulose (MFC) were synthesised using lyophilisation technique. The optimised scaffold with 0.1 % MFC, C(0.1 % ), showed highest compression modulus (¡«3.987 MPa) and glass transition temperature (¡«103 ¡ãC). The pore size for the control scaffold, C(0 % ), was in the range of 30-300 ¦Ìm while it was significantly reduced to 10-250 ¦Ìm in case of C(0.1 % ). Using micro computed tomography, the porosity of C(0.1 % ) was estimated to be 88 % . C(0.1 % ) showed excellent thermal stability and lower degradation rate compared to C(0 % ). The prepared samples were also characterised using XRD and FTIR. C(0.1 % ) showed controlled water uptake ability and in vitro degradation in PBS. It exhibited highest cell viability on NIH3T3 fibroblast cell line. These results suggest that these biocompatible composite scaffolds can be used for tissue engineering applications.