MiR-1180 promoted the proliferation of hepatocellular carcinoma cells by repressing TNIP2 expression

详细信息    查看全文

• 作者：Xu Zhou¹ ; Hua-qiang Zhu¹ ; Chao-qun Ma ; Hong-guang Li ; Fang-feng Liu ; Hong Chang ; Jun Lu ; ^{junlushandong@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：miR-1180 ; Hepatocellular carcinoma ; TNIP2 ; Cell proliferation
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：79
• 期：Complete
• 页码：315-320
• 全文大小：1457 K

文摘

MicroRNAs (miRNAs) are short, non-coding RNAs with post-transcriptional regulatory function, playing crucial roles in cancer development and progression of hepatocellular carcinoma (HCC). Previous studies have indicated that miR-1180 was implicated in diverse biological processes. However, the underlying mechanism of miR-1180 in HCC has not been intensively investigated. In this study, we aimed to investigate the role of miR-1180 and its target genes in HCC. We found that miR-1180 expression was significantly increased in HCC cells and clinical tissues compared with their corresponding controls. Overexpression of miR-1180 promoted cell proliferation in HCC cell line HepG2. TNFAIP3 interacting protein 2 (TNIP2), a potential target gene of miR-1180, and were validated by a luciferase assay. Further studies revealed that miR-1180 regulated cell proliferation of HCC by directly suppressing TNIP2 expression and the knockdown of TNIP2 expression reversed the effect of miR-1180-in on HCC cell proliferation. In summary, our data indicated that miR-1180 might act as a tumor promoter by targeting TNIP2 during development of HCC.