Mitotic Exit Function of Polo-like Kinase Cdc5 Is Dependent on Sequential Activation by Cdk1
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- 作者：Jose-Antonio Rodriguez-Rodriguez1 ; Yolanda Moyano1 ; Soraya Já ; tiva1 ; Ethel Queralt1 ; equeralt@idibell.cat" class="auth_mail" title="E-mail the corresponding author
- 关键词：mitosis ; Cdc5 polo kinase ; Cdc14 phosphatase ; Cdc fourteen early anaphase release ; mitotic exit network
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：31 May 2016
- 年：2016
- 卷：15
- 期：9
- 页码：2050-2062
- 全文大小：4723 K
文摘
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Cdc5-mediated Cdc14 activation is regulated by sequential Cdk1 phosphorylation
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Phosphorylation of Cdc5 at T242 and T70 regulate its kinase activity
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Cdk1 initially phosphorylates Cdc5 at its activation loop, mostly at T242
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Cdc5 T70 phosphorylation by Cdk1 is important for Cdc5-MEN function