Human CYP2E1-dependent mutagenicity of mono- and dichlorobiphenyls in Chinese hamster (V79)-derived cells
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- 作者：Chiteng Zhanga ; 1 ; Yanmei Laia ; 1 ; Guifang Jina ; Hansruedi Glattb ; c ; Qinzhi Weia ; Yungang Liua ; yungliu@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CYP2E1 ; Gene mutations ; Micronuclei ; Polychlorinated biphenyls ; Sulfotransferase 1A1
- 刊名：Chemosphere
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：144
- 期：Complete
- 页码：1908-1915
- 全文大小：1117 K
文摘
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A series of dichlorobiphenyls are mutagenic in V79-derived cells.
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The mutagenicity of dichlorobiphenyls is dependent on human CYP2E1.
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Human CYP2E1 is not active in activating monochlorobiphenyls to mutagens.