Spectrum of α-thalassemia and β-thalassemia mutations in the Guilin Region of southern China
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- 作者：Wenjun Tanga ; 1 ; tangwenjun56@qq.com" class="auth_mail" title="E-mail the corresponding author ; Chonglin Zhangb ; 1 ; 1019953306@qq.com" class="auth_mail" title="E-mail the corresponding author ; Fangfang Luc ; 2842322584@qq.com" class="auth_mail" title="E-mail the corresponding author ; Juan Tangb ; 875200286@qq.com" class="auth_mail" title="E-mail the corresponding author ; Yu Lua ; twj.abc@163.com" class="auth_mail" title="E-mail the corresponding author ; Xiu Cuib ; 540925911@qq.com" class="auth_mail" title="E-mail the corresponding author ; Xue Qina ; qinxue919@126.com" class="auth_mail" title="E-mail the corresponding author ; Shan Lia ; lis8858@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Thalassemia ; Mutation ; Spectrum ; Guilin Region
- 刊名：Clinical Biochemistry
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：48
- 期：16-17
- 页码：1068-1072
- 全文大小：1158 K
文摘
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We investigated the spectrum of α- or β- thalassemia mutations in 11,143 anemic patients in Guilin Region, China.
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CD41–42 is the most prevalent β- thalassemia mutation and —SEA is the most prevalent α-thalassemia mutation in Guilin Region.
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CD37 and CD 30 were two particularly rare dominant β- thalassemia mutations in Chinese populations.
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α- and β- thalassemia mutations of 8 regions in southern China were compared.
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Our findings provided new information for genetic counseling on thalassemia.