Synthesis and CHK1 inhibitory potency of Hymenialdisine analogues

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• 作者：Jean-Gilles Parmentier ; Bernard Portevin ; Roy M. Golsteyn ; Alain Pierré ; John Hickman ; Philippe Gloanec ; Guillaume De Nanteuil
• 关键词：Hymenialdisine ; CHK1 inhibitor
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2009
• 出版时间：1 February 2009
• 年：2009
• 卷：19
• 期：3
• 页码：841-844
• 全文大小：155 K

文摘

A series of thieno[3,2-b]pyrroloazepinones derivatives related to Hymenialdisine were prepared and tested for CHK1 inhibitory activity. Nanomolar inhibitions were achieved when electron-withdrawing substituents were introduced at position 3 of the thiophene ring.