CD166-mediated epidermal growth factor receptor phosphorylation promotes the growth of oral squamous cell carcinoma
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- 作者：Guodong Jiaa ; b ; c ; Xu Wanga ; b ; Ming Yana ; b ; Wantao Chena ; b ; ; Ping Zhanga ; b ; pingzhang73@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CD166 ; EGFR ; Phosphorylation ; Oral squamous cell carcinoma
- 刊名：Oral Oncology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：59
- 期：Complete
- 页码：1-11
- 全文大小：3558 K
文摘
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Identifying EGFR as a potential CD166 interaction protein, and a subsequent endogenous co-IP assay confirmed this interaction.
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Finding that CD166 significantly enhanced EGFR phosphorylation and prolonged EGF/EGFR signalling pathway activation.
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Pinpointing the CD166 as an intriguing therapeutic target for patients suffered from oral squamous cell carcinoma.