Biologically inspired survival analysis based on integrating gene expression as mediator with genomic variants
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- 作者：Ibrahim Youssefa ; b ; Robert Clarkec ; Ie-Ming Shihd ; Yue Wanga ; Guoqiang Yua ; yug@vt.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Survival analysis ; Survival feature selection ; Genomic data integration ; Gene expression ; Copy number alterations
- 刊名：Computers in Biology and Medicine
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：77
- 期：Complete
- 页码：231-239
- 全文大小：1255 K
文摘
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Integrating clinical and multi-omics data for survival analysis.
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Preserving the biological hierarchy from DNA to RNA.
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Three layers of data: clinical, transcriptomic, and genomic variants.
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Statistically building and linking the mechanistic model to the clinical model.
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Better prediction with statistically significant and biologically relevant genes.