4-Nitroimidazole-3-hydroxyflavone conjugate as a fluorescent probe for hypoxic cells
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- 作者：Weipei Fenga ; Yuechai Wanga ; Shizhu Chena ; Chao Wanga ; Shuxiang Wanga ; b ; wsx@hbu.cn" class="auth_mail" title="E-mail the corresponding author ; Shenghui Lia ; b ; Hongyan Lib ; Guoqiang Zhoua ; b ; Jinchao Zhanga ; b ; jczhang6970@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：4-Nitroimidazole ; Hypoxic trigger ; 3-HF-NO2 ; Off-on fluorescent probe ; Monitor hypoxic level
- 刊名：Dyes and Pigments
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：131
- 期：Complete
- 页码：145-153
- 全文大小：1282 K
文摘
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4-Nitroimidazole moiety is an efficient hypoxic trigger.
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A novel probe 3-HF-NO2 for the selective detection hypoxia or NTR was developed.
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3-HF-NO2 showed excellent selectivity, sensitivity, and low detection limit.
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3-HF-NO2 was successfully used for monitoring hypoxic status in HeLa cells.