Regulation of Smoothened Trafficking and Hedgehog Signaling by the SUMO Pathway
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- 作者：Guoqiang Ma1 ; 5 ; Shuang Li1 ; 2 ; 5 ; Yuhong Han1 ; 2 ; Shuangxi Li1 ; 2 ; Tao Yue1 ; 4 ; Bing Wang1 ; 2 ; Jin Jiang1 ; 2 ; 3 ; 6 ; jin.jiang@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：hedgehog ; Smo ; SUMO ; Ulp1 ; GPCR ; Shh ; USP8 ; primary cilium ; PKA ; Gli
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：21 November 2016
- 年：2016
- 卷：39
- 期：4
- 页码：438-451
- 全文大小：4640 K
文摘
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Sumoylation promotes Smo cell-surface expression and Hh signaling
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Hh stimulates Smo sumoylation by dissociating it from Ulp1
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Sumoylation inhibits Smo ubiquitination by recruiting UBPY
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Sumoylation regulates mSmo ciliary accumulation and Shh signaling