Short sleep duration is associated with insulin resistance independent of adiposity in Chinese adult twins

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• 作者：Rong  ; Liu^a ; Phyllis C.  ; Zee^b ; Ronald D.  ; Chervin^c ; Lester M.  ; Arguelles^a ; Jennafer  ; Birne^a ; Shanchun  ; Zhang^a ; Katherine Kaufer  ; Christoffel^a ; Wendy J.  ; Brickman^d ; Donald  ; Zimmerman^d ; Binyan  ; Wang^a ; Guoying  ; Wang^a ; Xiping  ; Xu^e ; Xiaobin  ; Wang^a ;   ; ^{xbwang@childrensmemorial.org}
• 关键词：Sleep duration ; Insulin resistance ; Adiposity ; Gender ; Rural ; Adults
• 刊名：Sleep Medicine
• 出版年：2011
• 出版时间：October 2011
• 年：2011
• 卷：12
• 期：9
• 页码：914-919
• 全文大小：202 K

文摘

Objective

To investigate the association between sleep duration and insulin resistance in rural Chinese adults and examine whether any such associations are independent of adiposity.

Methods

This is a cross-sectional analysis of 854 men and 640 women aged 20 to 70 years from the Anqing Twin Cohort. The following measures were obtained for each subject: Body mass index (BMI) and percentage of trunk fat ( % TF), fasting plasma glucose, homeostatic model assessment of insulin resistance index (HOMA-IR), self-reported sleep duration and measures of snoring and sleep disturbance from the Pittsburgh Sleep Quality Indices (PSQI) questionnaire were modified for a Chinese population. Multivariate linear regressions were applied to examine the association of sleep duration with HOMA-IR, with and without adjustment for adiposity variables, along with other relevant covariates.

Results

In this sample of relatively lean rural Chinese adults, short sleep duration was associated with HOMA-IR in women but not in men. In women, short (? h/night) sleep duration was associated with a higher HOMA-IR (p = 0.003) compared with normal sleep duration (>7 to ? h/night) after adjustment for all the covariates except adiposity. Further adjustment for BMI or % TF attenuated the sleep-HOMA-IR association, but the association remained significant upon adjustment for BMI (p = 0.013); and upon adjustment for % TF (p = 0.026). Long sleep duration (>8 h/night) was not significantly associated with HOMA-IR.

Conclusion

In this rural Chinese cohort, short sleep duration is independently associated with increased insulin resistance among women only, even after adjusting for adiposity and other potential confounders.