Acute and sub-chronic toxicity study of diaveridine in Wistar rats
详细信息 查看全文
- 作者：Xu Wanga ; 1 ; Shijia Sua ; 1 ; Awais Ihsand ; Qin Huangb ; Dongmei Chenb ; Guyue Chengb ; Zhenli Liuc ; Yulian Wangc ; wangyulian@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Zonghui Yuana ; b ; c ; yuan5802@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Diaveridine ; Acute study ; Sub-chronic study ; Toxicity ; Diaminopyrimidines
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：73
- 期：1
- 页码：232-240
- 全文大小：2074 K
文摘
- •
LD50 of diaveridine was 2330 and 3100 mg/kg bw for females and males, respectively.
- •
Chromodacryorrhea was noted in some females before their death.
- •
Significant pathological changes were noted in kidneys, adrenals and liver.
- •
The target organs of diaveridine were kidneys, adrenals and liver.
- •
The NOAEL for subchronic toxicity of diaveridine was 21.0–23.5 mg/kg bw/day for rats.