Clinical characteristics of chemotherapy-induced alopecia in childhood

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• 作者：Mira Choi ; Min Sun Kim ; Song Youn Park ; Gyeong Hun Park ; Seong Jin Jo ; Kwang Hyun Cho ; Ji Won Lee ; Kyung Duk Park ; Hee Young Shin ; Hyoung Jin Kang ; Ohsang Kwon
• 关键词：alopecia ; chemotherapy ; chemotherapy-induced alopecia ; childhood ; hematopoietic stem cell transplantation ; permanent ; thiotepa
• 刊名：Journal of the American Academy of Dermatology
• 出版年：March, 2014
• 年：2014
• 卷：70
• 期：3
• 页码：499-505
• 全文大小：616 K

文摘

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Background

Chemotherapy-induced alopecia (CIA) is a frequent complication in patients with cancer. There are an increasing number of reports of permanent CIA.

Objective

We investigated the clinical characteristics of CIA, including permanent CIA in childhood.

Methods

We collected data on 159 pediatric patients who had undergone high-dose conditioning chemotherapy followed by hematopoietic stem cell transplantation and 167 control subjects, using a questionnaire, medical record reviews, and phototrichograms.

Results

Alopecia began at 1.5聽卤聽1.4聽months and was sustained until 2.2聽卤聽1.6聽months after chemotherapy initiation. Hair regrowth started 2.6聽卤聽1.6聽months after chemotherapy ceased and lasted for 7.3聽卤聽4.9聽months. The mean hair density and thickness were 198.3聽卤聽47.4/cm² and 76.3聽卤聽18.4聽渭m in the patient group and 229.6聽卤聽34.5/cm² and 79.5聽卤聽12.4聽渭m in the control group, respectively (both, P聽<聽.001). In all, 19 (12%) patients experienced permanent CIA. Thiotepa use was identified as a significant risk factor for permanent CIA (odds ratio 7.57, P聽=聽.002).

Limitations

Cross-sectional study in a single-center is a limitation.

Conclusion

CIA is common in pediatric patients. Use of thiotepa is strongly associated with permanent CIA.