刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:26 February 2017
年:2017
卷:484
期:1
页码:21-26
全文大小:802 K
卷排序:484
文摘
Conformational entropy plays critical roles in the regulation of protein-protein interactions. Conformational entropy change upon binding of disordered ligands to a protein is not well understood. We estimated backbone conformational entropy change upon complexation of SH3 domain and PRM. Energetic contribution of backbone conformational entropy is significant in SH3-PRM interaction.