Evidence of susceptibility to lamivudine-based HAART and genetic stability of hepatitis B virus (HBV) in HIV co-infected patients: A South African longitudinal HBV whole genome study
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- 作者：Edina Amponsah-Dacostaa ; J. Nare Rakgolea ; Maemu P. Gededzhaa ; Azwidowi Lukhwarenia ; b ; Jason T. Blackardc ; Selokela G. Selabea ; M. Jeffrey Mphahlelea ; d ; Jeffrey.Mphahlele@mrc.ac.za" class="auth_mail" title="E-mail the corresponding author ; jeffmphahlele@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：HBV ; Hepatitis B virus ; HIV ; Human immunodeficiency virus ; HBsAg ; Hepatitis B surface antigen ; 3TC ; Lamivudine ; HAART ; Highly active anti-retroviral therapy
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：43
- 期：Complete
- 页码：232-238
- 全文大小：1075 K
文摘
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HIV positive patients experienced persistent HBV chronic infection despite exposure to long term 3TC-based HAART.
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Notably, primary drug resistant variants were not isolated prior to or during 3TC-based HAART.
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Overall, divergence rates of HBV isolates were indicative of minimal genetic variability overtime.