Thiol dependent NF-κB suppression and inhibition of T-cell mediated adaptive immune responses by a naturally occurring steroidal lactone Withaferin A
详细信息 查看全文
- 作者：Lokesh Gambhira ; Rahul Checkera ; Deepak Sharmaa ; M. Thoha ; Anand Patilb ; M. Deganic ; Vikram Gotab ; Santosh K. Sandura ; sskumar@barc.gov.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Anti-inflammatory ; Cytokines ; ROS ; Graft-versus-host disease ; Pharmacokinetics
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2015
- 出版时间：1 December 2015
- 年：2015
- 卷：289
- 期：2
- 页码：297-312
- 全文大小：2621 K
文摘
- •
Withaferin A (WA) inhibited T-cell and B-cell mediated immune responses.
- •
WA increased basal ROS levels in lymphocytes.
- •
WA directly interacted with GSH as studied using spectrophotometry and HPLC.
- •
WA inhibited NF-κB nuclear translocation and binding of nuclear NF-κB to DNA.
- •
WA inhibited induction of the graft-versus-host disease in mice.