Anchorless forms of prion protein - Impact of truncation on structure destabilization and prion protein conversion
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- 作者：Valerija Kovača ; Iva Hafner-Bratkovičb ; c ; Vladka Čurin &Scaron ; erbeca ; vladka.curin@ztm.si" class="auth_mail" title="E-mail the corresponding author ; valerija.hladnik@ztm.si" class="auth_mail" title="E-mail the corresponding author
- 关键词：Prion protein ; Anchorless ; Truncation ; Stop mutation ; Amyloid
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：2 December 2016
- 年：2016
- 卷：481
- 期：1-2
- 页码：1-6
- 全文大小：801 K
文摘
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Truncation effects prion protein stability and fibrillization properties.
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Protein destabilization and fibrillization properties are affected by pH and truncation.
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Important intramolecular interactions between loop β2−α2 and C-terminus of helix α3.