Pharmacokinetics of 21 active components in focal cerebral ischemic rats after oral administration of the active fraction of Xiao-Xu-Ming decoction
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- 作者：Caihong Wang ; Zhixin Jia ; Zhe Wang ; Ting Hu ; Hailin Qin ; Guanhua Du ; Caisheng Wu1 ; wucsh@xmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Jinlan Zhang1 ; zhjl@imm.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Xiao-Xu-Ming decoction ; Pharmacokinetic ; Ischemic stroke ; Reverse molecular docking ; Synergistic effect
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：110-117
- 全文大小：1968 K
文摘
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The Xiao-Xu-Ming decoction (XXMD) is clinically used to treat stroke.
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21 compounds from XXMD were selected as candidates via reverse molecular docking.
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HPLC–MS/MS method was developed to quantify 21 compounds in rat plasma and brain.
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Pharmacokinetics was compared between control and cerebral ischemic rats.
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Pharmacokinetic behaviors were characterized in cerebral ischemic rats.