Porous-wall hollow glass microspheres as novel potential nanocarriers for biomedical applications
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- 作者：Shuyi Li ; Lynsa Nguyen ; Hairong Xiong ; Meiyao Wang ; Tom C.-C. Hu ; Jin-Xiong She ; Steven M. Serkiz ; George G. Wicks ; William S. Dynan
- 关键词：Drug delivery ; Microsphere ; Silica ; Mesoporous ; Controlled release ; Single-chain antibody ; Single-chain antibody variable fragment ; Small interfering RNA
- 刊名：Nanomedicine: Nanotechnology, Biology and Medicine
- 出版年：2010
- 出版时间：February 2010
- 年：2010
- 卷：6
- 期：1
- 页码：127-136
- 全文大小：1681 K
文摘
Porous-wall hollow glass microspheres (PW-HGMs) are a novel form of glass material consisting of a 10- to 100-μm-diameter hollow central cavity surrounded by a 1-μm-thick silica shell. A tortuous network of nanometer-scale channels completely penetrates the shell. We show here that these channels promote size-dependent uptake and controlled release of biological molecules in the 3- to 8-nm range, including antibodies and a modified single-chain antibody variable fragment. In addition, a 6-nm (70-kDa) dextran can be used to gate the porous walls, facilitating controlled release of an internalized short interfering RNA. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anticancer drugs. The combination of a hollow central cavity that can carry soluble therapeutic agents with mesoporous walls for controlled release is a unique characteristic that distinguishes PW-HGMs from other glass materials for biomedical applications.
From the Clinical Editor
Porous-wall hollow glass microspheres (PW-HGMs) are a novel form of glass microparticles with a tortuous network of nanometer-scale channels. These channels allow size-dependent uptake and controlled release of biological molecules including antibodies and single-chain antibody fragments. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anti-cancer drugs.