The effects of amlodipine and enalapril on renal function in adults with hypertension and nondiabetic nephropathies: A 3-year, randomized, multicenter, double-blind, placebo-controlled study

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• 作者：Vincent L.M. Esnault ; Edwina A. Brown ; Eduard Apetrei ; Jacques Bagon ; Carlos Calvo ; Rudolf DeChatel ; Hallvard Holdaas ; Silvester Krcmery ; Zhanna Kobalava ; for the Amlodipine Versus Enalapril in Renal
• 关键词：angiotensin-converting enzyme inhibitors ; calcium channel blockers ; diuretics ; randomized placebo-controlled trial ; proteinuria ; chronic renal failure ; glomerular filtration rate
• 刊名：Clinical Therapeutics
• 出版年：2008
• 出版时间：March 2008
• 年：2008
• 卷：30
• 期：3
• 页码：482-498
• 全文大小：315 K

文摘

Background: Placebo-controlled trials have found that angiotensin-converting enzyme inhibitors (ACEIs) decrease proteinuria and slow the progression of nondiabetic nephropathies. However, head-to-head comparisons of ACEIs and calcium channel blockers (CCBs) have shown conflicting results. Indeed, a recent metaanalysis concluded that there is still uncertainty about the greater renoprotection seen with ACEIs or angiotensin II receptor blockers in nondiabetic patients with renal disease, particularly when using true glomerular filtration rate (GFR) as the primary outcome.