Anthelmintic activity of Saba senegalensis (A.DC.) Pichon (Apocynaceae) extract against adult worms and eggs of Haemonchus contortus

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• 作者：Mohamed Bonewendé ; Belemlilga¹ ; ² ; ^{medilga@yahoo.fr" class="auth_mail" title="E-mail the corresponding author} ; Aristide Traoré ; ² ; Sylvin Oué ; draogo² ; Adama Kaboré ; ³ ; Hamidou Hamadou Tamboura³ ; Innocent Pierre Guissou¹ ; ²
• 关键词：Saba senegalensis ; Anthelmintic properties ; Haemonchus contortus ; In vitro ; Burkina Faso
• 刊名：Asian Pacific Journal of Tropical Biomedicine
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：6
• 期：11
• 页码：945-949
• 全文大小：423 K

文摘

To evaluate the anthelmintic property of Saba senegalensis (A.DC) Pichon (Apocynaceae) (S. senegalensis) on Haemonchus contortus that is traditionally used in Burkina Faso for its gastrointestinal parasites treatment.

Methods

The lyophilized aqueous decoction of leaves of S. senegalensis at concentrations of 0.10, 1.00, 3.00, 10.00 and 15.00 mg/mL was used on eggs and adult worms of Haemonchus contortus collected from gastrointestinal tract of small ruminant.

Results

The LC₅₀ on adult worms was 6.79 mg/mL and 3.25 mg/mL for the leaves of S. senegalensis and the levamisole (reference drug), respectively. Inhibition of hatching assay showed a concentration-dependent manner with an inhibition of 93.63% at the concentration of 15.00 mg/mL of S. senegalensis.

Conclusions

These results indicate that the aqueous extract of S. senegalensis possesses an anthelmintic property and may justify its use in traditional medicine for the treatment of gastrointestinal parasites.