Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols

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• 作者：Marjan Ajami^a ; ¹ ; Hamidreza Pazoki-Toroudi^b ; ¹ ; Hamed Amani^b ; ¹ ; Seyed Fazel Nabavi^c ; Nady Braidy^d ; ^{n.braidy@unsw.edu.au} ; Rosa Anna Vacca^e ; ^{r.vacca@ibbe.cnr.it} ; Atanas Georgiev Atanasov^f ; ^g ; Andrei Mocan^h ; Seyed Mohammad Nabavi^c ; ^{Nabavi208@gmail.com}
• 关键词：Ageing ; Neurodegeneration ; Polyphenolic ; SIRT1&lrm ; Sirtuins
• 刊名：Neuroscience & Biobehavioral Reviews
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：73
• 期：Complete
• 页码：39-47
• 全文大小：1656 K
• 卷排序：73

文摘

Sirtuins play an important regulatory role in the ageing processes in humans. SIRT1-mediated neuroprotection has been attributed to its deacetylase activity. Extensive evidences show the therapeutic effects of polyphenols on neurodegeneration. Can polyphenols mitigate neurodegentation by targeting of SIRT1 pathway?