Tuning into immunological dissonance: an experimental model for infectious mononucleosis

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• 作者：Doherty ; Peter C ; Tripp ; Ralph A ; Hamilton-Easton ; Anne-Marie ; Cardin ; Rhonda D ; Woodland ; David L ; et. al.
• 关键词：CLN cervical lymph node ; EBV Epstein&mdash ; Barr virus ; γ ; -HV γ ; -herpesvirus ; IFN-1 type 1 interferon ; Ig immunoglobulin ; IM infectious mononucleosis ; LCMV lymphocytic choriomeningitis virus ; mAb monoclonal antibody ; MHV-68 murine γ ; -herpesviru
• 刊名：Current Opinion in Immunology
• 出版年：1997
• 出版时间：August, 1997
• 年：1997
• 卷：9
• 期：4
• 页码：477-483
• 全文大小：575 K

文摘

Virus infections cause a much more profound perturbation of the lymphoid tissue than can be accounted for by the exigencies of the antigen-specific response. The extent of this ‘immunological dissonance’ is seen most dramatically in mice infected with a persistent γ-herpesvirus, MHV-68. A profile of massive, continuing proliferation of both T and B cells in the lymph nodes and spleen leads to a dramatic increase in the prevalence of a CD62L^low CD8⁺ T cell subset in the blood, a pattern first detected two to three weeks after intranasal exposure to the inducing virus. This syndrome, which seems identical to human infectious mononucleosis (IM), persists for a further month or more. Part of the IM-like phase of MHV-68 infection reflects the selective expansion of Vβ4⁺ CD8⁺ T cells, with the Vβ4 effect being apparent for several different MHC class I H-2 types but not in mice that are deficient in MHC class II glycoprotein expression. Depleting CD4⁺ T helper cells in MHV -68-infected mice leads to the decreased proliferation of the CD8⁺ T cells in the spleen and fewer CD62L^low CD8⁺ T lymphocytes than would be expected in peripheral blood, but fails to diminish the prominence of the V4β⁺ CD8⁺ population. The results so far of this unique experimental mouse model of IM suggest that both cytokine-mediated effects and a viral superantigen are operating to promote the dramatic expansion and persistence of activated CD8⁺ T cells in the vascular compartment.