Prevalence of chronic kidney disease and associated factors in Chinese individuals with type 2 diabetes: Cross-sectional study

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• 作者：Kaifeng Guo¹ ; Lei Zhang¹ ; Fangya Zhao ; Junxi Lu ; Pan Pan ; Haoyong Yu ; Yuqian Bao ; Haibing Chen ; ^{chenhb@sjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Weiping Jia ; ^{wpjia@sjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Chronic kidney disease ; Diabetic kidney disease ; Hyperfiltration ; Prevalence ; Albuminuria ; Type 2 diabetes
• 刊名：Journal of Diabetes and its Complications
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：30
• 期：5
• 页码：803-810
• 全文大小：630 K

文摘

This cross-sectional study aimed to determine the prevalence and associated risk factors of chronic kidney disease (CKD) in Chinese type 2 diabetic patients.

Methods

A total of 3301 patients with type 2 diabetes were included in this study. Anthropometric parameters and biochemical indices were measured. The main outcome measures were detection of CKD, albuminuria and estimated glomerular filtration rate (eGFR).

Results

The prevalence of CKD and albuminuria in Shanghai Chinese type 2 diabetic patients was 27.1% and 25.2%. The prevalence of mildly decreased renal function or worse (eGFR < 60/mL/min/1.73 m²) was 6%. The prevalence of glomerular hyperfiltration was 12.2%. The prevalence of diabetic kidney disease (DKD) according to the newest NKF’s KDOQI classification was 12.03%. Risk factors associated with DKD were SBP, retinopathy, neuropathy, TG, LDL, anemia and HbA1c. Clinical factors associated with both albuminuria and low eGFR (≥ 60/< 60) were SBP, retinopathy, TC, TG and anemia.

Conclusion

In conclusion, CKD and DKD were common in the Shanghai Chinese patients with T2DM and were similar to that in Western patients. Prevention and control of diabetes should be a high priority in reducing the CKD burden in China.