Harmonization of description and classification of fetal observations: Achievements and problems still unresolved: Report of the 7th Workshop on the Terminology in Developmental Toxicology Berlin, 4-6 May 2011

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• 作者：Roland Solecki^a ; ^{Roland.Solecki@bfr.bund.de} ; Stephane Barbellion^b ; Brigitte Bergmann^c ; Heinrich Bü ; rgin^d ; Jochen Buschmann^e ; Ruth Clark^f ; Laura Comotto^g ; Antje Fuchs^h ; Ali Said Faqiⁱ ; Ralph Gerspach^j ; Konstanze Grote^k ; Helen Hakansson^l ; Verena Heinrich^a ; Barbara Heinrich-Hirsch^a ; Thomas Hofmann^c ; Ulrich Hü ; bel^m ; Thelma Helena Inazakiⁿ ; Samia Khalil^d ; Thomas B. Knudsen^o ; Sabine Kudicke^p ; Wolfgang Lingk^y ; Susan Makris^o ; Simone Mü ; ller^q ; Francisco Paumgartten^r ; Rudolf Pfeil^a ; Elkiane Macedo Ramaⁿ ; Steffen Schneider^s ; Kohei Shiota^t ; Eva Tamborini^g ; Mariska Tegelenbosch^u ; Beate Ulbrich^a ; E.A.J. van Duijnhoven^v ; David Wise^w ; Ibrahim Chahoud^x
• 关键词：Malformation ; Variation ; Grey zone anomalies ; Non-human primates ; Developmental toxicology ; Reproductive toxicology ; Terminology glossary
• 刊名：Reproductive Toxicology
• 出版年：2013
• 出版时间：January, 2013
• 年：2013
• 卷：35
• 期：Complete
• 页码：48-55
• 全文大小：269 K

文摘

This article summarizes the 7th Workshop on the Terminology in Developmental Toxicology held in Berlin, May 4-6, 2011. The series of Berlin Workshops has been mainly concerned with the harmonization of terminology and classification of fetal anomalies in developmental toxicity studies. The main topics of the 7th Workshop were knowledge on the fate of anomalies after birth, use of Version 2 terminology for maternal-fetal observations and non-routinely used species, reclassification of ¡°grey zone¡± anomalies and categorization of fetal observations for human health risk assessment.

The paucity of data on health consequences of the postnatal permanence of fetal anomalies is relevant and further studies are needed. The Version 2 terminology is an important step forward and the terms listed in this glossary are considered also to be appropriate for most observations in non-routinely used species.

Continuation of the Berlin Workshops was recommended. Topics suggested for the next Workshop were grouping of fetal observations for reporting and statistical analysis.