Missteps in Current Estimates of Cancer Overdiagnosis

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• 作者：Christoph I. Lee ; MD ; MSHS^a ; ^b ; ^{stophlee@uw.edu} ; Ruth Etzioni ; PhD^c
• 关键词：Overdiagnosis ; overtreatment ; mammography ; cancer screening
• 刊名：Academic Radiology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：24
• 期：2
• 页码：226-229
• 全文大小：106 K
• 卷排序：24

文摘

The balance between the benefits and harms of imaging-based cancer screening continues to be an area of controversy and widespread media attention. Of the potential harms, overdiagnosis from screening is likely the most elusive in estimating and quantifying. This article describes the major methodological issues with recently reported estimates of overdiagnosis that are based on excess cancer incidence, and suggests that modeling focused on tumor lead-time can serve as a complementary method for excess incidence-based overdiagnosis estimates. Radiologists should be conversant on the topic of overdiagnosis and understand the limitations of different methods used to estimate its magnitude.