Opening the lid on piano-stool complexes: An account of聽ruthenium(II)-arene complexes with medicinal applications
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- 作者：Alexey A. Nazarov ; Christian G. Hartinger ; Paul J. Dyson
- 关键词：Bioorganometallic chemistry ; Piano-stool compounds ; Ruthenium arene complexes ; Anticancer drugs ; Antimetastasis drugs ; Targeted chemotherapy
- 刊名：Journal of Organometallic Chemistry
- 出版年：1 February, 2014
- 年：2014
- 卷：751
- 期：Complete
- 页码：251-260
- 全文大小：1379 K
文摘
Interest in the medicinal properties of ruthenium(II)-arene compounds has grown rapidly over the last decade. In this account we describe the origins of the field and subsequently highlight developments in the field, including the design of compounds that inhibit enzymes, the application of multinuclear systems to act as drug delivery vehicles, and the development of bioanalytical and biophysical methods to help elucidate the mechanisms by which these compounds function. The conducive properties and reasons for the rapid growth in interest in these and related compounds for their medicinal applications, especially in the treatment of solid tumours, are identified.